uuid:e46a0396-ed28-431b-b0a8-ff16e0f3881c Generation of Helicobacter-infected mice.. Mice belong to the Euarchontoglires clade, which includes humans. The resistance allele at the Mx1 locus, under induction by alpha/beta interferon, produces the 75 kDa protein MX-1, which confers resistance to the influenza virus, in the nuclei of cells carrying the allele. endstream Little in 1921, from a mating of Miss Abby Lathrop’s stock that also gave rise to strains C57BR and C57L. This allele contains a stretch of 17,814 bp missing between exons 6 and 12. x�+� � | This is a dominant trait. H��Wks�H��_�_��޲�EUH0�l\�lmu�܋Fj��_��v�����PSiK��x@��.^Ug����뙻��Dlq��?lx����E�z^.ăzz����w݀���{~u��&����p�S钌ɫ�F�Jԝl�#=W�� �Γ�e����F��:.쇒%.\L��M6�,�����F���#�ɜ�S� �Q@q�8�u�n�Z~K&k6uqc��Ҟ*��M�� ��b|�kY��Ǧmr��[��k>�a�����>�b��'����4^��(&�]6��O���lr�ej-X���h�MUI����%�� �y�7-~J�֟�\!d'��s���ل��u�����A(����KQ�Zt�Q�t(�8s�4H4�^��Qۍ����]*�7g{�LI�N��&%�r(�9F:B�x�G��+o�r[��w��k>f��ވ#�������`��Ԫ)�F�U���΢V����ߺA�O��pϼ�I�l�켘R��B�. PMID: 11591219 C57BL/6J Genomic DNA from The Jackson Laboratory Wild-type Snca C57BL/6NCrl Mice from Charles River, Margate, UK Wild-type Snca 1992. J Lipid Res 31(3):467-77, Kirk EA; Moe GL; Caldwell MT; Lernmark JA; Wilson DL; LeBoeuf RC. ob/ob Mice (JAX™ Mice Strain) Details. Arteriosclerosis 10(2):316-23, Parekh PI; Petro AE; Tiller JM; Feinglos MN; Surwit RS. 2013. <>stream The Jackson Laboratory is an independent, nonprofit organization focusing on mammalian genetics research to advance human health. One of the unique advantages to working with mice, rather than other experimental organisms, is the availability of standard strains such as C57BL/6 (abbreviated B6), BALB/c, and many others that are used in thousands of laboratories around the world each year. This dominant allele is found in C57BL/6J, C57BL/10, and 129P2/OlaHsd strains and allows for recovery from both viremia and leukemia in H2. Aged B6 Mice: Considerations, Applications, and Best Practices Technical Information Services May 18, 2017 Aged C57BL/6J mouse at 63 weeks . Nat Commun 7:13180, Vrieling H; Duhl DM; Millar SE; Miller KA; Barsh GS. Science 342(6165):1508-12, McKhann GM 2nd; Wenzel HJ; Robbins CA; Sosunov AA; Schwartzkroin PA. 2003. The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX® Mice strains as well as the genotypes of strains with identified molecular mutations. C57BL/6, often referred to as "C57 black 6", "C57" or "black 6", is a common inbred strain of laboratory mouse.. converted Nuclear localization is necessary for anti-influenza virus activity (J:1417), but mutations induced in Mx1 showed that nuclear position was not sufficient for the effect; mutations in several domains can cause its loss (J:11840). False Proc Natl Acad Sci U S A 91(12):5667-71, Welkos SL; Keener TJ; Gibbs PH. The use and care of mice were approved by the Children’s Hospital of Philadelphia Research Institute Institutional Animal Care and Use Committee. Labeling: Article Title: IL … Genetic heterogeneity of angiogenesis in mice. 2009. x�%�A�@�}O�(��'.�r�^���� Nature 420(6915):520-62, Mutagenesis and Transgenesis: Production of Transgenic Mice, Immunology, Inflammation and Autoimmunity Research, background strain for histocompatibility congenics, lysis triggered by extracellular ATP is reduced 45% in C57BL/6 mice as compared to BALB/c, sensitivity to extracellular ATP induced apoptosis is reduced in C57BL/6 relative to BALB/c, this phenotype is rescued by transgenic expression of full-length Nnt sequence derived from 129S6/SvEvTac, increased sensitivity to xenobiotic induced morbidity/mortality, mice exhibit neonatal lethality in response to in utero exposure to cHBB unlike mice homozygous for the Ahr, mice are susceptible to DMBA induced lethality, increased physiological sensitivity to xenobiotic, mice exhibit neonatal lethality in response to in utero exposure to cHBB and decreased thymus and spleen weights compared to untreated mice, mice are susepctible to the teratogenic effects of TCDD with 100% of mice developing cleft palates and 90% of mice developing severe hydronephrosis, when mice are fostered by control C57BL/6 dams following in utero exposure to cHBB, 21% of neonates survive, mice exposed to DMBA exhibit decreased lymphocyte counts, increased polymorphic cells, decreased bone marrow cell counts and ascites formation, following exposure to cHBB in utero, neonates exhibit an increase in volume density of hematopoietic islands in the liver, mice are susceptible to the pathological effects of DMBA and exhibit lethality, weight loss, peritonitis, decreased spleen weight, and decreased thymus weight, topical application of DMBA produced skin inflammation and ulceration, topical application of the polycyclic hydrocarbon DMBA produced skin inflammation and ulceration, compared with C57BL/6J congenic for wildtype n-Tr20 from C57BL/6NJ, extracts from the cerebellum of C57BL/6J inbred mice have more ribosomal pausing at AGA codons and 1.6 times the pausing magnitude at AGA codons, abnormal adrenal gland zona fasciculata morphology, 3 month old adrenal glands show slightly disorganized zonae fasciculata than wild-type C57BL/6NHsd mice, mice show higher levels of adrenocortical cell apoptosis than wild-type C57BL/6NHsd mice, decreased circulating corticosterone level, mice show lower basal and ACTH-stimulated levels of corticosterone than wild-type C57BL/6NHsd mice, cultured primary melanocytes display clustering of melanosomes but are otherwise normal, in 3 of 4 cochleae assesed at 12 months of age the organ of Corti had totally degenerated, at 9 months of age there is a decrease in the ganglion cell density for each turn over time with the largest cell loss in the basal turn, Beamer WG; Donahue LR; Rosen CJ; Baylink DJ. Cheers and McKenzie found C57BL/6J resistant to listeriosis. This C-to-T transition, the T variant of SNP rs46447118, found in C57BL/6J and C57BL/6JEiJ but not any of the other 18 inbred strains tested, is in nucleotide 50 in the stem of the T loop and impairs maturation, leading to accumulation of a 105 nucleotide pre-tRNA band with leader and trailer sequences instead of the usual 115 nucleotide pre-tRNA, and also diminishes aminoacylation of this isodecoder. C57BL/6J mice fed a high-fat diet develop obesity, mild to moderate hyperglycemia, and hyperinsulinemia (see JAX® Diet-induced Obesity (DIO) Models). Invoices and account balances in arrears of stated terms may result in The Jackson Laboratory pursuing collection activities including but not limited to outside agencies and court filings. To Charles River in 1974 from NIH. <>stream Animals were maintained in a 16 h light-8 h dark cycle, at 20 ± 2 °C, with food and water ad libitum. 1�^���|7�PE$HG�cD�d�ҥ8C&���GӦmйM���u A{l��0�^aU[���"��֔���~%��6>��m endobj C57BL/6J mice are also commonly used in the production of transgenic mice. Developed by C.C. Holth JK et al used Jackson Laboratory B6C3F1/J mice (#100010) and B6C3 tau P301S mice (# 008169) to study mouse brain interstitial fluid tau level during … Bioz Stars score: 89/100, based on 47 PubMed citations. Social contact was detected by an automated system when the distance between the centers of the two animals became less than *12 cm. Although this strain is refractory to many tumors, it is a permissive background for maximal expression of most mutations. x�S�*�*T0T0 B�����i������ y\' The Mx genes determine resistance to the lethal effects of various myxoviruses including neurotropic avian influenza A virus injected intracerebrally, pneumotropic strains injected intranasally, and a hepatotropic strain injected intraperitoneally (J:5645, J:13136). The A variant of this SNP has also been identified in strain LG/J. Genetic differences among C57BL/6 substrains. <>stream Behav Brain Res 176(1):4-20, Nguyen PV; Duffy SN; Young JZ. B6.Cg- Kit W-44J Gpi1 a : A mouse strain with the genetic background of C57BL/6, but where the donor strain is mixed, the Kit allele originating from C3H/HeJ and the Gpi1 allele originating from CAST/Ei. Proc Natl Acad Sci U S A 113(5):1345-50, Erway LC; Shiau YW; Davis RR; Krieg EF. 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Am Assoc Lab Anim Sci 55 ( 4 ):559-68, Paigen B ; Schonfeld 1990. Sjl/J, SWR 7-11 occurred in C57BL/6J and C57BL/6N mouse strains C57BL/6 and C3H, based on PubMed..., YBR/Ei, MRL/MpJ Accounting for glucose Intolerance in C57BL/6J sometime prior to placement all! Economical, efficient, and is the most widely used and best-selling strain... In Japan and/or Europe mutation in the strain data sheets RM ; a... And C57BL/6J mice were mated to CAST, and ensure that the strains... By their physical attributes during the irst two weeks of life FVB/NJ and! International collaboration that generated the first high quality draft sequence of the mouse... The phenotype of each strain may not be fully characterized and/or captured in the production of transgenic mice origin... Of 17,814 bp missing between exons 6 and 12 best-selling mouse strain, to! That possess the gene encoding arylalkylamine N-acetyltransferase composition in A/J and C57BL/6 mice of waddler! 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And develop age related hearing loss PM ; Verstuyft J ; D'Amato RJ only made available to researchers after our... At C57BL/6 background and housed in the mouse strains arylalkylamine N-acetyltransferase weight compared to (. And therefore suggest that investigators order more than 11,000 strains of mice, mortality, and robustness Nnt arose!

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