Abnormalities were detected at statistically similar rates between the two screening tests at all levels. October 28, 2009;302(16):1757–1764. Normal; Atypical squamous cells of undetermined significance (ASC-US). Front Med (Lausanne). Prevalence of Angiogenesis, Proliferation, and Apoptosis Markers of Cervical Cancer and Their Correlation with Clinicopathological Parameters. 2020 Apr 22;15:24. doi: 10.1186/s13027-020-00290-y. Zou Y, Tuo X, Wu L, Liu Y, Feng X, Zhao L, Han L, Wang L, Wang Y, Hou H, Shi G, Li Q. This randomized clinical trial compares the effects of cervical HPV vs cytology (Pap smear) screening on the cumulative incidence of high-grade cervical intraepithelial neoplasia (CIN3+) detected at … / Journals Another advantage of liquid-based cytology is that it allows for human papillomavirus typing to be performed on the specimen already collected if the Pap smear … cervical cytology and histopathology showed high sensitivity and specificity of Pap smear examination. JAMA. Epub 2019 Nov 20. Pap smear – older method, in which sample cells are transferred directly to slide for viewing; Liquid-based cytology – sample cells are placed in liquid solution for transport to the lab, whereby they are extracted for cytologic analysis. In this intention-to-treat analysis, 45,818 liquid-based cytology tests and 38,504 conventional Pap smears were reviewed. 2004 May;8(20):iii, 1-78. doi: 10.3310/hta8200. 2020 Jun;27(2):90-95. doi: 10.1177/0969141319885409. Widespread application of screening programs in recent decades has achieved significant reductions in cervical cancer incidence and mortality (4,5). Epub 2013 Jan 20. The comparative accuracy of each technique has been studied extensively and has yielded conflicting results; recent systematic reviews reported that there is no convincing evidence to recommend one technique over the other. Abstract. et al. Women with abnormal screening results were followed for 18 months, with clinically appropriate histologic testing (with colposcopy and biopsy) or repeat cervical cytology. The Dutch cervical screening program tests women every five years; sampling is done by family physicians. All rights Reserved. A Comparison of 3 Ways of Conventional Pap Smear, Liquid-Based Cytology and Colposcopy vs Cervical Biopsy for Early Diagnosis of Premalignant Lesions or Cervical Cancer in Women with Abnormal Conventional Pap Test Choose a single article, issue, or full-access subscription. LBC has been found to be more superior to conventional smears only with respect to lesser number of unsatisfactory smears, but considering the economic implications of LBC, conventional Pap is more feasible in our setting. Copyright © 2020 American Academy of Family Physicians. Choice of screening test also depends on the cytology laboratory in which the samples are processed; although liquid-based cytology is more expensive, its ease of use allows laboratories to process slides more quickly and efficiently. Home Strict implementation of screening programs has led to a large decrease in cervical cancer incidence and mortality in the developed countries. Aims: To evaluate Liquid Based Cytology (LBC) diagnostic performance compared with Conventional Pap Smear (CPS) for cervical cancer screening and to compare the sensitivity and specificity of the two cytology methods with gold standard cervical biopsy. eCollection 2020. The cervix connects the body of the uterus to the vagina. Don't miss a single issue. For many years, cytology-based screening, known as the Pap test or Pap smear, was the only method of screening. 2020 Jul 24;7:369. doi: 10.3389/fmed.2020.00369. All women and people with a cervix aged 25 to 64 should be invited by letter. Clipboard, Search History, and several other advanced features are temporarily unavailable. The study was undertaken to evaluate liquid based cytology (Pap spin) and to compare the sensitivity of Pap spin with conventional Pap smear. Methods: This is a hospital based cross-sectional study conducted from April 2017 to April 2018 in 110 sample randomly selected … Siebers and colleagues designed this prospective study to compare the histologic detection rates and positive predictive values of conventional Pap smears and liquid-based cervical cytology. Cervical screening in Western Kazakhstan: Liquid-based cytology 'Cell Scan' versus azur-eosin staining. Conclusion: The authors conclude that conventional Pap smears and liquid-based cytology screening tests have equivalent detection ratios and positive and negative predictive values for detecting CIN or cervical cancer. 1. In the UK alone, over 3 million cervical smears are performed annually. 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