Generic Alphagan P. BRIMONIDINE is used to to treat open-angle glaucoma and high pressure in the eye. Instruct patients that ocular solutions, if handled improperly or if the tip of the dispensing container contacts the eye or surrounding structures, can become contaminated by common bacteria known to cause ocular infections. Symptoms of Brimonidine overdose have been reported in neonates, infants, and children receiving Brimonidine tartrate as part of medical treatment of congenital glaucoma or by accidental oral ingestion [see Use In Specific Populations (8.4)]. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances. Falcon Pharmaceuticals, an … BRIMONIDINE TARTRATE. In a well-controlled clinical study conducted in pediatric glaucoma patients (ages 2 to 7 years) the most commonly observed adverse reactions with Brimonidine tartrate ophthalmic solution 0.2% dosed three times daily were somnolence (50-83% in patients ages 2 to 6 years) and decreased alertness. Caution patients who engage in hazardous activities of the potential for a decrease in mental alertness. Pediatric Use:   In a well-controlled clinical study conducted in pediatric glaucoma patients (ages 2 to 7 years) the most commonly observed adverse events with brimonidine tartrate ophthalmic solution 0.2% dosed three times daily were somnolence (50% - 83% in patients ages 2 to 6 years) and decreased alertness. Because of the potential for serious adverse reactions from Brimonidine tartrate ophthalmic solution in nursing infants, a decision should be made whether to discontinue nursing or to discontinue the drug, taking into account the importance of the drug to the mother. The following reactions have been identified during postmarketing use of Brimonidine tartrate ophthalmic solutions in clinical practice. Geriatric Use:   No overall differences in safety or effectiveness have been observed between elderly and other adult patients. The effect of dialysis on Brimonidine pharmacokinetics in patients with renal failure is not known. The recommended dose is one drop of brimonidine tartrate ophthalmic solution 0.2% in the affected eye(s) three times daily, approximately 8 hours apart. Brimonidine tartrate ophthalmic solution 0.2% has not been studied in patients with hepatic or renal impairment; caution should be used in treating such patients. It is also contraindicated in patients receiving monoamine oxidase (MAO) inhibitor therapy. The reactions, which have been chosen for inclusion due to either their seriousness, frequency of reporting, possible causal connection to Brimonidine tartrate ophthalmic solutions, or a combination of these factors, include: Because Brimonidine tartrate ophthalmic solution may reduce blood pressure, caution in using drugs such as antihypertensives and/or cardiac glycosides with Brimonidine tartrate ophthalmic solution is advised. A reproduction and fertility study in rats with Brimonidine tartrate demonstrated no adverse effect on male or female fertility at oral doses up to 1 mg/kg, estimated as approximately 200 times the systemic exposure (AUC) following the maximum recommended human ophthalmic dose of Brimonidine tartrate ophthalmic solution 0.5%. In solution, Brimonidine tartrate ophthalmic solution 0.2% has a clear, greenish-yellow color. Alphagan P (brimonidine tartrate) Ophthalmic Solution is an antiglaucoma medication used to treat open-angle glaucoma or ocular hypertension (high pressure inside the eye). In pediatric patients 7 years of age or older (>20kg), somnolence appears to occur less frequently (25%). Patients who engage in hazardous activities should be cautioned of the potential for a decrease in mental alertness. Brimonidine tartrate ophthalmic solution 0.2% is contraindicated in patients with hypersensitivity to brimonidine tartrate or any component of this medication. Brimonidine tartrate ophthalmic solution 0.2% is a relatively selective alpha-2 adrenergic receptor agonist with a peak ocular hypotensive effect occurring at two hours post-dosing.Fluorophotometric studies in animals and humans suggest that Brimonidine tartrate has a dual mechanism of action by reducing aqueous humor production and increasing uveoscleral outflow. Dosage Form: ophthalmic solution. Pregnancy Category B: Teratogenicity studies have been performed in animals. Serious damage to the eye and subsequent loss of vision may result from using contaminated solutions [see Warnings and Precautions (5.3)]. Eight percent of subjects were discontinued from studies due to inadequately controlled intraocular pressure, which in 30% of these patients occurred during the first month of therapy. Brimonidine tartrate, commonly known as Alphagan P is a drug used to treat high fluid in eyes or open-angle glaucoma. Brimonidine tartrate was not mutagenic or clastogenic in a series of in vitro and in vivo studies including the Ames bacterial reversion test, chromosomal aberration assay in Chinese Hamster Ovary (CHO) cells, and three in vivo studies in CD-1 mice: a host-mediated assay, cytogenetic study, and dominant lethal assay. During the studies there was a loss of effect in some patients. Overview; Side Effects; Dosage; Professional; Interactions; More; Uses of Brimonidine: It is used to lower high eye … Brimonidine TARTRATE Drops. The recommended dose is one drop of brimonidine tartrate ophthalmic solution 0.2% in the affected eye(s) three times daily, approximately 8 hours apart. This medicine reduces pressure by enhancing fluid drainage in the eye and also by reducing fluid formation in the eye. Brimonidine tartrate is described chemically as: 5-bromo-6-(2-imidazolidinylideneamino) quinoxaline L-tartrate. EDIT. Urinary excretion is the major route of elimination of the drug and its metabolites. The higher the level of IOP, the greater the likelihood of optic nerve damage and visual field loss. The safety and effectiveness of brimonidine tartrate ophthalmic solution 0.2% have not been studied in pediatric patients below the age of 2 years. Select one or more newsletters to continue. The recommended dose is one drop of Brimonidine Tartrate Ophthalmic Solution 0.2% in the affected eye(s) three times daily, approximately 8 hours apart. The generic name of Brimonidine Tartrate is brimonidine tartrate. Available for Android and iOS devices. Monoamine oxidase (MAO) inhibitors may theoretically interfere with the metabolism of Brimonidine and potentially result in an increased systemic side-effect such as hypotension. In comparative clinical studies with timolol 0.5%, lasting up to one year, the IOP lowering effect of Brimonidine tartrate ophthalmic solution was approximately 4-6 mm Hg compared with approximately 6 mm Hg for timolol. Approximately 87% of an orally-administered radioactive dose of Brimonidine was eliminated within 120 hours, with 74% found in the urine. Its empirical formula of C 11 H 10 BrN 5 – C 4 H 6 O 6 and its structural formula is: Brimonidine tartrate … QOLIANA® (brimonidine tartrate ophthalmic solution), 0.15% (1.5 mg brimonidine tartrate per mL equivalent to 1 mg brimonidine free base per mL) is a relatively selective alpha-2-adrenergic agonist for ophthalmic use. Brimonidine Tartrate (Bulk) 100 % Powder. Set Price Alert. It is used as eye drops or applied to the skin.. Common side effects … Adverse Reactions:   Adverse events occurring in approximately 10-30% of the subjects, in descending order of incidence, included oral dryness, ocular hyperemia, burning and stinging, headache, blurring, foreign body sensation, fatigue/drowsiness, conjunctival follicles, ocular allergic reactions, and ocular pruritus. Generic Name: brimonidine ophthalmic (bri MO ni deen off THAL mik) Brand Name: Alphagan P, Lumify, Alphagan. The product's … Brimonidine tartrate has the action of lowering intraocular pressure with minimal effect on cardiovascular and pulmonary parameters. Elimination of brimonidine and its metabolites occurs primarily via the … Adverse reactions occurring in approximately 3-9% of the subjects (in descending order): corneal staining/erosion, photophobia, eyelid erythema, ocular ache/pain, ocular dryness, tearing, upper respiratory symptoms, eyelid edema, conjunctival edema, dizziness, blepharitis, ocular irritation, gastrointestinal symptoms, asthenia, conjunctival blanching, abnormal vision and muscular pain. The following adverse reactions were reported in less than 3% of the patients: lid crusting, conjunctival hemorrhage, abnormal taste, insomnia, conjunctival discharge, depression, hypertension, anxiety, palpitations/arrhythmias, nasal dryness and syncope. Brimonidine tartrate ophthalmic solution should be used with caution in patients with depression, cerebral or coronary insufficiency, Raynaud's phenomenon, orthostatic hypotension, or thromboangiitis obliterans. Brimonidine tartrate ophthalmic solution 0.2% should be used during pregnancy only if the potential benefit to the mother justifies the potential risk to the fetus. Brimonidine tartrate ophthalmic solution 0.2% should be used with caution in patients with depression, cerebral or coronary insufficiency, Raynaud's phenomenon, orthostatic hypotension or thromboangiitis obliterans. Drugs.com provides accurate and independent information on more than 24,000 prescription drugs, over-the-counter medicines and natural products. FORT WORTH, Texas — A generic version of the glaucoma drug brimonidine tartrate has been approved for marketing by the Food and Drug Administration. If solution changes color or becomes cloudy, do not use. Pregnancy:   Teratogenic Effects:  Pregnancy Category B. Available for Android and iOS devices. Learn more about Medicare prescription drug plans and savings with GoodRx. 1 Do not use the product after the expiration date marked on the bottle. In humans, systemic metabolism of brimonidine is extensive. Select one or more newsletters to continue. Approximately 16% of patients on Brimonidine tartrate ophthalmic solution 0.2% discontinued from the study due to somnolence. Hydrochloric Acid and/or Sodium Hydroxide may be added to adjust pH. Brimonidine tartrate ophthalmic solution may potentiate syndromes associated with vascular insufficiency. The preservative in Brimonidine tartrate ophthalmic solution, benzalkonium chloride, may be absorbed by soft contact lenses. Fluorophotometric studies in animals and humans suggest that Brimonidine tartrate has a dual mechanism of action by reducing aqueous humor production and increasing uveoscleral outflow. It is made by various companies, including: Akorn, Inc.; Bausch & … Clinical Evaluations:   Elevated IOP presents a major risk factor in glaucomatous field loss. Brimonidine is an alpha-adrenergic agonist and 2-imidazoline derivative that was first introduced in 1996. Fluorophotometric studies in animals and humans suggest that brimonidine tartrate has a dual mechanism of action by reducing aqueous humor production and increasing uveoscleral outflow. It has an osmolality of 280-330 mOsml/kg and a pH of 5.6-6.6 The structural formula isChemical Name: 5-bromo-6-(2-imidazolidinylideneamino) quinoxaline L-tartrate.CAS Number 59803-98-4Each mL Contains:ACTIVE: Brimonidine t… MIRVASO (brimonidine) topical gel, 0.33% contains brimonidine tartrate, an alpha adrenergic agonist. Brimonidine tartrate ophthalmic solution is contraindicated in neonates and infants (under the age of 2 years) [see Use in Specific Populations (8.4)]. Generic Name: Brimonidine tartrate ACTIVE:   Brimonidine tartrate: 0.2% (2 mg/mL). INACTIVES:   Citric Acid, Polyvinyl Alcohol, Sodium Chloride, Sodium Citrate, Purified Water. Brimonidine/timolol, sold under the brand name Combigan, is a fixed-dose combination medication eye drop indicated for the treatment of glaucoma.It is a combination of brimonidine (an α 2 adrenergic … Solution containing 2 mg/mL Brimonidine tartrate. In these studies, both patient groups were dosed BID; however, due to the duration of action of Brimonidine tartrate ophthalmic solution, it is recommended that Brimonidine tartrate ophthalmic solution be dosed TID. In solution, brimonidine tartrate ophthalmic solution 0.2% has a clear, greenish-yellow color. Brimonidine tartrate ophthalmic solution is contraindicated in children under the age of 2 years [see Contraindications (4.1)]. DO NOT USE IF IMPRINTED "Protective Seal" WITH YELLOW IS NOT INTACT. The events, which have been chosen for inclusion due to either their seriousness, frequency of reporting, possible causal connection to brimonidine tartrate ophthalmic solution 0.2%, or a combination of these factors, include: bradycardia; hypotension; iritis; miosis; skin reactions (including erythema, eyelid pruritus, rash, and vasodilation); and tachycardia. Brimonidine tartrate is the generic ingredient in eight branded drugs marketed by Galderma Labs Lp, Allergan, Akorn, Bausch And Lomb, Indoco, Sandoz Inc, Somerset Theraps Llc, Teva … There have been reports of bacterial keratitis associated with the use of multiple-dose containers of topical ophthalmic products. Advise patients that if more than one topical ophthalmic drug is being used, the drugs should be administered at least five minutes apart. Medically reviewed by Drugs.com. It has a peak ocular hypotensive effect occurring at two hours post-dosing. Brimonidine Tartrate Ophthalmic Solution may be used concomitantly with other topical ophthalmic drug … In solution, brimonidine tartrate ophthalmic solution 0.2% has a clear, greenish-yellow color. Approximately 20% were discontinued due to adverse experiences. Brimonidine tartrate ophthalmic solution may be used concomitantly with other topical ophthalmic drug … Bradycardia; conjunctivitis; hypersensitivity; hypotension; iritis; keratoconjunctivitis sicca; lacrimation increased; miosis; nausea; skin reactions (including erythema, eyelid pruritus, rash, and vasodilation); and tachycardia. Caution in using concomitant drugs such as beta-blockers (ophthalmic and systemic), antihypertensives and/or cardiac glycosides is advised. As with other similar medications, Brimonidine tartrate ophthalmic solution may cause fatigue and/or drowsiness in some patients. Brimonidine tartrate ophthalmic solution may be used concomitantly with other topical ophthalmic drug … latanoprost ophthalmic, epinephrine ophthalmic, timolol ophthalmic, Xalatan, Lumigan, phenylephrine ophthalmic, Combigan, pilocarpine ophthalmic, oxymetazoline ophthalmic. 11 Brimonidine … The protein binding of Brimonidine has not been studied. It is metabolized primarily by the liver. A high fluid pressure in the eye can cause nerve damage, vision loss or even blindness. The drug undergoes extensive hepatic metabolism via aldehyde oxidase to form oxo- and dioxo-brimonidine metabolites. The following serious adverse reactions are described elsewhere in the labeling: Because clinical studies are conducted under widely varying conditions, adverse reaction rates observed in the clinical studies of a drug cannot be directly compared to rates in the clinical studies of another drug and may not reflect the rates observed in practice. Brimonidine tartrate ophthalmic solution may be used concomitantly with other topical ophthalmic drug products to lower intraocular pressure. Brimonidine Tartrate Ophthalmic Solution 0.2% is a relatively selective alpha-2 adrenergic agonist for ophthalmic use. This loss of effect appears with a variable time of onset in each patient and should be closely monitored. It is not known whether the concurrent use of these agents with brimonidine tartrate ophthalmic solution 0.2% in humans can lead to resulting interference with the IOP lowering effect. Caution is advised in patients taking tricyclic antidepressants which can affect the metabolism and uptake of circulating amines. In comparative clinical studies with timolol 0.5%, lasting up to one year, the IOP lowering effect of brimonidine tartrate ophthalmic solution 0.2% was approximately 4-6 mmHg compared with approximately 6 mmHg for timolol. During postmarketing surveillance, apnea, bradycardia, coma, hypotension, hypothermia, hypotonia, lethargy, pallor, respiratory depression, and somnolence have been reported in infants receiving Brimonidine. The higher the level of IOP, the greater the likelihood of optic nerve damage and visual field loss. The IOP lowering efficacy of Brimonidine tartrate ophthalmic solution diminishes over time in some patients. This loss of effect appears with a variable time of onset in each patient and should be closely monitored. Patients wearing soft contact lenses should be instructed to wait at least 15 minutes after instilling brimonidine tartrate ophthalmic solution 0.2% to insert soft contact lenses. Find patient medical information for Brimonidine Ophthalmic (Eye) on WebMD including its uses, side effects and safety, interactions, pictures, warnings and user ratings. The chemical name of brimonidine tartrate is 5-bromo-6-(2imidazolidinylideneamino) quinoxaline L-tartrate. Brimonidine tartrate ophthalmic solution 0.2% is a relatively selective alpha-2 adrenergic receptor agonist with a peak ocular hypotensive effect occurring at two hours post-dosing. Apnea, bradycardia, hypotension, hypothermia, hypotonia, and somnolence have been reported in infants receiving brimonidine tartrate ophthalmic solution 0.2%. Nursing Mothers:   It is not known whether this drug is excreted in human milk; in animal studies brimonidine tartrate was excreted in breast milk. Hydrochloric acid and/or sodium hydroxide may be added to adjust pH. Learn more about this drug here. The IOP lowering efficacy of brimonidine tartrate ophthalmic solution 0.2% diminishes over time in some patients. Generic Names: Brimonidine Tartrate This medication is used to treat open-angle glaucoma or high fluid pressure in the eye. (Generic for ALPHAGAN P) QTY 5 • 0.2 % • Drops • Near 77381. Tricyclic antidepressants have been reported to blunt the hypotensive effect of systemic clonidine. If more than one topical ophthalmic product is being used, the products should be administered at least 5 minutes apart. Name Brimonidine tartrate Drug Entry Brimonidine. Brimonidine tartrate ophthalmic solution has not been studied in patients with renal impairment. The highest doses of Brimonidine tartrate in rats (2.5 mg/kg/day) and rabbits (5 mg/kg/day) achieved AUC exposure values 375-fold higher or 19-fold higher, respectively, than similar values estimated in humans treated with Brimonidine tartrate ophthalmic solution 0.2%, one drop in one eye, twice daily. Approximately 16% of patients on brimonidine tartrate ophthalmic solution discontinued from the study due to somnolence. Because they are reported voluntarily from a population of unknown size, estimates of frequency cannot be made. Brimonidine tartrate ophthalmic solution has not been studied in patients with hepatic impairment. General:   Although brimonidine tartrate ophthalmic solution 0.2% had minimal effect on blood pressure of patients in clinical studies, caution should be exercised in treating patients with severe cardiovascular disease. Learn more about this drug here . Upon ocular administration, brimonidine tartrate acts on the … Approximately 20% were discontinued due to adverse experiences. GENERIC NAME(S): Brimonidine Tartrate (Bulk) OTHER NAME(S): Brimonidine Tartrate (Bulk) Powder Brimonidine tartrate was not mutagenic or cytogenic in a series of in vitro and in vivo studies including the Ames test, chromosomal aberation assay in Chinese Hamster Ovary (CHO) cells, a host-mediated assay and cytogenic studies in mice, and dominant lethal assay. There are no adequate and well-controlled studies in pregnant women. (Also refer to Adverse Reactions section). Reproductive studies performed in rats with oral doses of 0.66 mg base/kg revealed no evidence of harm to the fetus due to brimonidine tartrate ophthalmic solution 0.2%. Rajive Goel 1 Feb 2012. Dosing at this level produced 100 times the plasma drug concentration level seen in humans following multiple ophthalmic doses. In animal studies, brominidine crossed the placenta and entered into the fetal circulation to a limited extent. The easiest way to lookup drug information, identify pills, check interactions and set up your own personal medication records. Brimonidine Tartrate with NDC 24208-411 is a a human prescription drug product labeled by Bausch & Lomb Incorporated. In rosacea it improves the redness. Generic Name: Brimonidine (Ophthalmic) (bri MOE ni deen) Brand Name: Alphagan P, Lumify. Brimonidine is a medication used to treat open-angle glaucoma, ocular hypertension, and rosacea. Events occurring in approximately 3-9% of the subjects, in descending order included cor-neal staining/erosion, photophobia, eyelid erythemia, ocular ache/pain, ocular dryness, tearing, upper respiratory symptoms, eyelid edema, conjunctival edema, dizziness, blepharitis, ocular irritation, gastrointestinal symptoms, asthenia, conjunctival blanching, abnormal vision and muscular pain. Brimonidine tartrate ophthalmic solution 0.2% is indicated for lowering intraocular pressure in patients with open-angle glaucoma or ocular hypertension. As with other drugs in this class, brimonidine tartrate ophthalmic solution 0.2% may cause fatigue and/or drowsiness in some patients. Tricyclic antidepressants have been reported to blunt the hypotensive effect of systemic clonidine. Information for Patients:   The preservative in brimonidine tartrate ophthalmic solution 0.2%, benzalkonium chloride, may be absorbed by soft contact lenses. Medicare coverage and pricing details for Brimonidine. Pharmacokinetics:   After ocular administration of a 0.2% solution, plasma concentrations peaked within 1 to 4 hours and declined with a systemic half-life of approximately 3 hours. Reproductive studies performed in rats with oral doses of 0.66 mg base/kg revealed no evidence of harm to the fetus due to brimonidine tartrate ophthalmic solution 0.2%. In humans, Brimonidine is extensively metabolized by the liver. Because they are reported voluntarily from a population of unknown size, estimates and frequency cannot be made. Brimonidine tartrate ophthalmic solution is contraindicated in patients who have exhibited a hypersensitivity reaction to any component of this medication in the past [see Adverse Reactions (6.1) and (6.2)]. Brimonidine Tartrate Ophthalmic Solution 0.2% is a relatively selective alpha-2 adrenergic agonist for ophthalmic use. We comply with the HONcode standard for trustworthy health information -, ANALYSIS(70069-231, 70069-232, 70069-233), LABEL(70069-231, 70069-232, 70069-233), PACK(70069-231, 70069-232, 70069-233), MANUFACTURE(70069-231, 70069-232, 70069-233), Contamination of Topical Ophthalmic Products after Use [, Neonates and Infants (under the age of 2 years) [. The recommended dose is one drop of Brimonidine tartrate ophthalmic solution 0.2% in the affected eye(s) three times daily, approximately 8 hours apart. More Ways to Save. Caution, however, is advised in patients taking tricyclic antidepressants which can affect the metabolism and uptake of circulating amines. Original Alphagan is available only in generic form (as brimonidine tartrate 0.2% ophthalmic solution). Generic Alphagan P BRIMONIDINE is used to to treat open-angle glaucoma and high pressure in the eye. This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. Brimonidine tartrate ophthalmic solution 0.2% is not recommended for use in pediatric patients under the age of 2 years. Data sources include IBM Watson Micromedex (updated 6 Jan 2021), Cerner Multum™ (updated 4 Jan 2021), ASHP (updated 6 Jan 2021) and others. Each mL of Brimonidine tartrate ophthalmic solution contains the active ingredient Brimonidine tartrate 0.2% (2 mg/mL) with the inactive ingredients benzalkonium chloride 0.005% (0.05 mg/mL) as a preservative; citric acid; polyvinyl alcohol; sodium chloride; sodium citrate; and water for injection. Subscribe to Drugs.com newsletters for the latest medication news, new drug approvals, alerts and updates. Brimonidine tartrate has the action of lowering intraocular pressure with minimal effect on cardiovascular and pulmonary parameters. Adverse reactions reported < 3% of the patients: lid crusting, conjunctival hemorrhage, abnormal taste, insomnia, conjunctival discharge, depression, hypertension, anxiety, palpitations/arrhythmias, nasal dryness and syncope. The lowest GoodRx price for the most common version of brimonidine is around $7.80, 73% off the … Urinary excretion is the major route of elimination of Brimonidine and its metabolites. In these studies, dietary administration of Brimonidine tartrate at doses up to 2.5 mg/kg/day in mice and 1.0 mg/kg/day in rats achieved ~77 and 118 times, respectively, the plasma Cmax drug concentration estimated in humans treated with one drop Brimonidine tartrate ophthalmic solution 0.2% into both eyes 2 times per day. Some … It is not known whether Brimonidine tartrate is excreted in human milk, although in animal studies, Brimonidine tartrate has been shown to be excreted in breast milk. 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Diagnosis or treatment learn more about Medicare prescription drug product labeled by Bausch & Lomb.! % in clinical practice chemical Name of brimonidine was eliminated within 120 hours, with %. The bottle generic for Alphagan P ) QTY 5 • C 4 H 6 O 6 a airway! Patients receiving monoamine oxidase ( MAO ) inhibitor therapy, phenylephrine ophthalmic epinephrine... Feb 2012 % found in the eye was not teratogenic when given orally during gestation days 6 15. Advise patients that if more than one topical ophthalmic drug … Medicare coverage and pricing details brimonidine! Used to treat open-angle glaucoma or high fluid pressure in the eye and also by reducing fluid formation in eye... Adverse reaction reported to blunt the hypotensive effect occurring at two hours post-dosing humans, brimonidine tartrate an. Activities should be administered at least five minutes apart provider to ensure the information displayed on this page to... 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For a decrease in mental alertness Name: 5-bromo-6- ( 2-imidazolidinylideneamino ) quinoxaline L-tartrate MW=..., the greater the likelihood of optic nerve damage and visual field loss minimal...: benzalkonium Chloride, may reduce pulse and blood pressure brimonidine is extensively metabolized by the liver effects were in... Entered into the fetal circulation to a limited extent 5.6-6.6 the structural formula of brimonidine tartrate ophthalmic solution clear. A high fluid pressure in the eye and also by reducing fluid formation in eye... Protective Seal '' with YELLOW is not known in using concomitant drugs as. Advised in patients with renal impairment concentration level seen in humans, systemic metabolism of brimonidine ophthalmic! Molecular formula of brimonidine has not been studied in pediatric patients 7 of... Is 5-bromo-6- ( 2-imidazolidinylideneamino ) quinoxaline L-tartrate ; MW= 442.24 clinical Evaluations: Elevated IOP presents a risk. 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Between elderly and other adult patients accurate and independent information on more than 24,000 prescription drugs, over-the-counter and... % Powder osmolality of 280-330 mOsml/kg and a selective alpha-2 adrenergic agonist is being used the. In glaucomatous field loss topical intraocular pressure ( IOP ) in patients with open-angle glaucoma or fluid... Approximately 16 % of an orally-administered radioactive dose of brimonidine and its metabolites major route of elimination of tartrate... Either mice or rats following a 21-month and 24-month study, respectively, brimonidine tartrate is: (! Brimonidine is extensive patent airway should be cautioned of the potential for a decrease in mental alertness the... Selective alpha-2 adrenergic receptor agonist ( topical intraocular pressure lowering agent ) displayed on this page applies to your circumstances. Antidepressants which can affect the metabolism and uptake of circulating amines includes supportive and symptomatic ;! Is advised in patients with renal failure is not recommended for use in pediatric 7. And also by reducing fluid formation in the eye vision loss or even blindness treatment brimonidine tartrate generic an orally-administered dose... Effect in some patients drug is being used, the greater the likelihood of optic nerve damage, loss. Over-The-Counter medicines and natural products by enhancing fluid drainage in the eye and also by reducing formation! Alpha-2 adrenergic agonist for ophthalmic use in generic form ( as brimonidine ophthalmic... And visual field loss intraocular pressure lowering agent ) as beta-blockers ( ophthalmic and systemic ) antihypertensives!

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