failure receiving a sub-optimal dose of RAASi therapy. However, kidney function was defined by a single baseline serum creatinine level within 12 months and single follow-up creatinine level within 2 months of RAASI therapy initiation. But what if there was a better way to lower potassium levels so that these patients could reach those target doses? and enabling optimal RAASi therapy in patients with CKD. ARBs), while angioedema and hyperkalemia may occur in both ARBs and ACE inhibitor use. Sub-study 1 is about patients with new diagnosis of heart failure with reduced ejection fraction (HFrEF) and how often these patients develop hyperkalaemia over 1 year and if hyperkalaemia leads to any changes to RAASi. mmol/l) alongside standard treatment with insulin -glucose and salbutamol. Clinicians often struggle to optimize guideline-directed medical therapy in patients with heart failure and frequently lower RAASi therapies in response to episodes of hyperkalemia, which translates into an increased risk for poor outcomes. 2 Interestingly, RAASis seem to induce hyperkalemia even in patients receiving maintenance dialysis, 10 most likely due to their effect on gastrointestinal potassium secretion. They block the production of angiotensin II, a substance that narrows blood vessels and releases hormones such as aldosterone … Methods: A patient-level simulation model was designed to fully characterise the natural history of CKD over a lifetime horizon, and predict the associations between serum potassium levels, RAASi use … Reported percentages of RAASi therapy (single or dual) discontinuation due to hyperkalemia from randomized trials of various patient groups (e.g. The proposed study consists of 2 sub-studies. Such an approach is already implemented in other fields of medicine, e.g. Definition of RAASi in the Abbreviations.com acronyms and abbreviations directory. Angiotensin-converting enzyme inhibitors (ACE inhibitors) are a group of medicines that are mainly used to treat certain heart and kidney conditions; however, they may be used in the management of other conditions such as migraine and scleroderma.. Reported percentages of RAASi therapy (single or dual) discontinuation due to hyperkalemia from randomized trials of various patient groups (e.g. Patiromer Patiromer is an oral potassium binder approved by NICE in February 2020 for the following indications: +life-threatening hyperkalaemia (K ≥ . Renin-angiotensin-aldosterone system inhibitors. A dramatic reduction of adherence to RAASi therapy was observed among adherent patients after HK onset: only 41.9% of patients remained adherent to therapy, while 36.4% were considered as non‐adherent (PDC <80%) and 21.7% discontinued the treatment, as recommended by ESC guidelines. This page is about the meanings of the acronym/abbreviation/shorthand RAASi in the Medical field in general and in the Drugs terminology in particular. hypertension or heart failure) have been relatively low (0.4–8.1% [3,20]) while data on the patterns of RAASi therapy following hyperkalemia in CKD in routine clinical settings are limited. A common side effect of ACE inhibitors is a bradykinin-induced cough, which may necessitate switching to an alternative therapy (e.g. In this study the adjusted incidence rates of hyperkalemia in CKD patients with and without RAASi therapy were 8.22 and 1.77 per 100 patient-months, respectively. 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